A Soluble Form of CTLA-4 Is Present in Paediatric Patients with Acute Lymphoblastic Leukaemia and Correlates with CD1d(+) Expression

CTLA-4 is a key factor in regulating and maintaining self tolerance, providing a negative signal to the T cell and thus limiting immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased risk of developing autoimmune diseases and, very recently, with susce...

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Autors principals: Simone, Rita, Tenca, Claudya, Fais, Franco, Luciani, Matteo, De Rossi, Giulio, Pesce, Giampaola, Bagnasco, Marcello, Saverino, Daniele
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458033/
https://ncbi.nlm.nih.gov/pubmed/23049754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044654
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