Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog

Recombinant human FVIIa (rhFVIIa) corrects the coagulopathy in hemophilia A and B as well as FVII deficiency. This is also the case in dogs until canine anti-human FVIIa antibodies develop (~2 weeks). Recombinant canine factor VIIa (rcFVIIa), successfully over-expressed by gene transfer in haemophil...

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Main Authors: KNUDSEN, T., KRISTENSEN, A. T., NICHOLS, T. C., AGERSØ, H., JENSEN, A. L., KJALKE, M., EZBAN, M., TRANHOLM, M.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925423/
https://ncbi.nlm.nih.gov/pubmed/21645178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2516.2011.02536.x
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