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Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration
The ability of injured axons to regenerate declines with age yet the mechanisms that regulate axon regeneration in response to age are not known. Here we show that axon regeneration in aging C. elegans motor neurons is inhibited by the conserved insulin/IGF1 receptor DAF-2. DAF-2’s function in regen...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3924874/ https://ncbi.nlm.nih.gov/pubmed/24440228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.11.019 |
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