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Introduction of D-Phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides
The purpose of this study was to examine whether the introduction of D-Phe could improve the GnRH receptor binding affinities of DOTA-conjugated D-Lys(6)-GnRH peptides. Building upon the construct of DOTA-Ahx-(D-Lys(6)-GnRH1) we previously reported, an aromatic amino acid of D-Phe was inserted eithe...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3924789/ https://ncbi.nlm.nih.gov/pubmed/24418777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.12.120 |
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