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Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire
Immature B cells are generated daily in the bone marrow tissue. More than half of the newly generated immature B cells are autoreactive and bind a self-antigen, while the others are nonautoreactive. A selection process has evolved on the one hand to thwart development of autoreactive immature B cell...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3924590/ https://ncbi.nlm.nih.gov/pubmed/22941591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12026-012-8366-7 |
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