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Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset
Cdh1, a coactivator of the anaphase-promoting complex (APC), is a potential tumor suppressor. Cdh1 ablation promotes precocious S-phase entry, but it was unclear how this affects DNA replication dynamics while contributing to genomic instability and tumorigenesis. We find that Cdh1 depletion causes...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923637/ https://ncbi.nlm.nih.gov/pubmed/24356446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-08-0480 |
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