A Common Single Nucleotide Polymorphism A118g of the Mu Opioid Receptor Alters Its N-glycosylation and Protein Stability

The A118G single nucleotide polymorphism (SNP) of the human mu opioid receptor (hMOPR) gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous for G118 allele were reported to require higher morphine doses to achieve adequate analgesia and G118 allele was more prevalent among dr...

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Hlavní autoři: Huang, Peng, Chen, Chongguang, Mague, Stephen D, Blendy, Julie A, Liu-Chen, Lee-Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923516/
https://ncbi.nlm.nih.gov/pubmed/21864297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111050
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