C6 knock-out Mice Are Protected from Thrombophilia Mediated by Antiphospholipid Antibodies

BACKGROUND: Complement activation plays a role in pathogenesis of the Antiphospholipid Syndrome (APS), but the involvement of the C5b-9 membrane attack complex (MAC) is unknown. Here we studied the effects of human polyclonal antiphospholipid (aPL) antibodies on thrombosis and tissue factor (TF) up-...

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Bibliographische Detailangaben
Hauptverfasser: Laura, Carrera-Marín Ana, Zurina, Romay-Penabad, Elizabeth, Papalardo, Elba, Reyes-Maldonado, Ethel, Garcia-Latorre, Gracie, Vargas, Tuya, Shilagard, Silvia, Pierangeli
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923322/
https://ncbi.nlm.nih.gov/pubmed/22933620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0961203312458839
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