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First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP(5) kinase
We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Royal Society of Chemistry
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923271/ https://ncbi.nlm.nih.gov/pubmed/23032903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc36044f |
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