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Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
Inositol pyrophosphates (such as IP7 and IP8) are multifunctional signaling molecules that regulate diverse cellular activities. Inositol pyrophosphates have ‘high-energy’ phosphoanhydride bonds, so their enzymatic synthesis requires that a substantial energy barrier to the transition state be overc...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923263/ https://ncbi.nlm.nih.gov/pubmed/22119861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.733 |
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