Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host

In Gram-negative bacteria, acquired 16S rRNA methyltransferases ArmA and NpmA confer high-level resistance to all clinically useful aminoglycosides by modifying, respectively, G1405 and A1408 in the A-site. These enzymes must coexist with several endogenous methyltransferases that are essential for...

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Bibliographic Details
Main Authors: Lioy, Virginia S., Goussard, Sylvie, Guerineau, Vincent, Yoon, Eun-Jeong, Courvalin, Patrice, Galimand, Marc, Grillot-Courvalin, Catherine
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923132/
https://ncbi.nlm.nih.gov/pubmed/24398977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.042572.113
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