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Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis

ChrX cellular mosaicism for X-linked genetic polymorphisms in females versus the single ChrX representation in males denotes a genetic difference, which may contribute to gender bias in the inflammatory response. This hypothesis was tested in female F1 offspring of consomic mice (BL6J-ChrX(A/J)/NaJ)...

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Autors principals: Chandra, Rachna, Federici, Stephanie, Németh, Zoltán H., Csóka, Balázs, Thomas, James A., Donnelly, Robert, Spolarics, Zoltán
Format: Artigo
Idioma:Inglês
Publicat: Society for Leukocyte Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923084/
https://ncbi.nlm.nih.gov/pubmed/24193737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0713397
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