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Insufficient autoantigen presentation and failure of tolerance in a mouse model of rheumatoid arthritis
OBJECTIVE: In the K/BxN mouse model of rheumatoid arthritis, T cells reactive for the self-antigen glucose-6-phosphate isomerase (GPI) escape negative selection even though GPI expression is ubiquitous. We sought to determine whether insufficient GPI presentation could account for the failure of neg...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923054/ https://ncbi.nlm.nih.gov/pubmed/23840022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38085 |
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