Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors

BACKGROUND: The expression of annexin A6 (AnxA6) in AnxA6-deficient non-invasive tumor cells has been shown to terminate epidermal growth factor receptor (EGFR) activation and downstream signaling. However, as a scaffolding protein, AnxA6 may stabilize activated cell-surface receptors to promote cel...

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Detalhes bibliográficos
Main Authors: Koumangoye, Rainelli B, Nangami, Gladys N, Thompson, Pamela D, Agboto, Vincent K, Ochieng, Josiah, Sakwe, Amos M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922904/
https://ncbi.nlm.nih.gov/pubmed/24354805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-167
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