PIK3CA Mutations Frequently Coexist with EGFR/KRAS Mutations in Non-Small Cell Lung Cancer and Suggest Poor Prognosis in EGFR/KRAS Wildtype Subgroup

PURPOSE: PIK3CA gene encoding a catalytic subunit of the phosphatidylinositol-3-kinase (PI3K) is mutated and/or amplified in various neoplasia, including lung cancer. Here we investigated PIK3CA gene alterations, the expression of core components of PI3K pathway, and evaluated their clinical importa...

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Detalhes bibliográficos
Main Authors: Wang, Lei, Hu, Haichuan, Pan, Yunjian, Wang, Rui, Li, Yuan, Shen, Lei, Yu, Yongfu, Li, Hang, Cai, Deng, Sun, Yihua, Chen, Haiquan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922761/
https://ncbi.nlm.nih.gov/pubmed/24533074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088291
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