PIK3CA Mutations Frequently Coexist with EGFR/KRAS Mutations in Non-Small Cell Lung Cancer and Suggest Poor Prognosis in EGFR/KRAS Wildtype Subgroup

PURPOSE: PIK3CA gene encoding a catalytic subunit of the phosphatidylinositol-3-kinase (PI3K) is mutated and/or amplified in various neoplasia, including lung cancer. Here we investigated PIK3CA gene alterations, the expression of core components of PI3K pathway, and evaluated their clinical importa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Lei, Hu, Haichuan, Pan, Yunjian, Wang, Rui, Li, Yuan, Shen, Lei, Yu, Yongfu, Li, Hang, Cai, Deng, Sun, Yihua, Chen, Haiquan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922761/
https://ncbi.nlm.nih.gov/pubmed/24533074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088291
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