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Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture.

We have developed a culture system for detecting and isolating rare hypoxanthine phosphoribosyltransferase-deficient mutants of human epidermal keratinocytes. A thioguanine-resistant variant, 3T3M1, of the Swiss mouse fibroblast line 3T3 was used as a feeder layer to support clonal growth of mutant...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Allen-Hoffmann, B L, Rheinwald, J G
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1984
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392240/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6440145/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.24.7802
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