Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model

Fragile X syndrome (FXS), the most common inherited form of intellectual disability and prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that prevents transcription and translation of fragile X mental retardation protein (FMRP). FMRP binds to and controls translat...

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Main Authors: Goebel-Goody, Susan M., Wilson-Wallis, Evan D., Royston, Sara, Tagliatela, Stephanie, Naegele, Janice R., Lombroso, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922131/
https://ncbi.nlm.nih.gov/pubmed/22405502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1601-183X.2012.00781.x
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