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Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
Fragile X syndrome (FXS), the most common inherited form of intellectual disability and prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that prevents transcription and translation of fragile X mental retardation protein (FMRP). FMRP binds to and controls translat...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3922131/ https://ncbi.nlm.nih.gov/pubmed/22405502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1601-183X.2012.00781.x |
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