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Keeping p53 in Check: A High-Stakes Balancing Act
How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. (2010) now use single-cell microscopy to demonstrate that alternative posttranslational modifications allow the tumor suppressor p53 to differentiate between benign breaks in DNA during the cell cycle...
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| Natura: | Artigo |
| Lingua: | Inglês |
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2010
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3922053/ https://ncbi.nlm.nih.gov/pubmed/20603009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.026 |
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