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β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia
Microglial activation worsens neuronal loss and contributes to progressive neurological diseases like Parkinson's disease (PD). This inflammatory progression is countered by dynorphin (Dyn), the endogenous ligand of the kappa-opioid receptor (KOR). We show that microglial β-arrestin mediates th...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3921587/ https://ncbi.nlm.nih.gov/pubmed/24162663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.152 |
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