Thymidylate synthase expression and p21(WAF1)/p53 phenotype of colon cancers identify patients who may benefit from 5-fluorouracil based therapy

BACKGROUND: Studies on the expression of thymidylate synthase (TS) in colorectal cancers (CRCs) have failed to provide unequivocal prognostic or predictive information. Here, we assessed the prognostic significance of TS expression in Astler-Coller stage B2 and C CRCs defined by a p21(WAF1)/p53 immu...

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Main Authors: Sulzyc-Bielicka, Violetta, Domagala, Pawel, Bielicki, Dariusz, Safranow, Krzysztof, Domagala, Wenancjusz
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2013
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921584/
https://ncbi.nlm.nih.gov/pubmed/24277474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13402-013-0159-z
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