Thymidylate synthase expression and p21(WAF1)/p53 phenotype of colon cancers identify patients who may benefit from 5-fluorouracil based therapy

BACKGROUND: Studies on the expression of thymidylate synthase (TS) in colorectal cancers (CRCs) have failed to provide unequivocal prognostic or predictive information. Here, we assessed the prognostic significance of TS expression in Astler-Coller stage B2 and C CRCs defined by a p21(WAF1)/p53 immu...

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Bibliografiske detaljer
Main Authors: Sulzyc-Bielicka, Violetta, Domagala, Pawel, Bielicki, Dariusz, Safranow, Krzysztof, Domagala, Wenancjusz
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2013
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921584/
https://ncbi.nlm.nih.gov/pubmed/24277474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13402-013-0159-z
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