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Correction of the Crb1(rd8) Allele and Retinal Phenotype in C57BL/6N Mice Via TALEN-Mediated Homology-Directed Repair
PURPOSE. We directly corrected the mouse Crb1(rd8) gene mutation, which is present in many inbred laboratory strains derived from C57BL/6N and complicates genetic studies of retinal disease in mice. METHODS. Fertilized C57BL/6NJ oocytes were coinjected with mRNAs encoding a transcription activator-l...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Association for Research in Vision and Ophthalmology
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3921157/ https://ncbi.nlm.nih.gov/pubmed/24346171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13278 |
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