Correction of the Crb1(rd8) Allele and Retinal Phenotype in C57BL/6N Mice Via TALEN-Mediated Homology-Directed Repair

PURPOSE. We directly corrected the mouse Crb1(rd8) gene mutation, which is present in many inbred laboratory strains derived from C57BL/6N and complicates genetic studies of retinal disease in mice. METHODS. Fertilized C57BL/6NJ oocytes were coinjected with mRNAs encoding a transcription activator-l...

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Main Authors: Low, Benjamin E., Krebs, Mark P., Joung, J. Keith, Tsai, Shengdar Q., Nishina, Patsy M., Wiles, Michael V.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921157/
https://ncbi.nlm.nih.gov/pubmed/24346171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13278
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