Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants

Autophagy is a critical regulator of organellar homeostasis, particularly of mitochondria. Upon the loss of membrane potential, dysfunctional mitochondria are selectively removed by autophagy through recruitment of the E3 ligase Parkin by the PTEN-induced kinase 1 (PINK1) and subsequent ubiquitinati...

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Detalhes bibliográficos
Main Authors: de Castro, I P, Costa, A C, Celardo, I, Tufi, R, Dinsdale, D, Loh, S H Y, Martins, L M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920958/
https://ncbi.nlm.nih.gov/pubmed/24157867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.394
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