Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants

Autophagy is a critical regulator of organellar homeostasis, particularly of mitochondria. Upon the loss of membrane potential, dysfunctional mitochondria are selectively removed by autophagy through recruitment of the E3 ligase Parkin by the PTEN-induced kinase 1 (PINK1) and subsequent ubiquitinati...

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Bibliografiske detaljer
Main Authors:	de Castro, I P, Costa, A C, Celardo, I, Tufi, R, Dinsdale, D, Loh, S H Y, Martins, L M
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2013
Fag:	Original Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3920958/ https://ncbi.nlm.nih.gov/pubmed/24157867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.394
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Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants

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