Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction of the synthesized serine is routed to a pathway for ATP production. The pathway is composed by reactions from serine synthesis, one-carbon...

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Detalhes bibliográficos
Main Authors: Tedeschi, P M, Markert, E K, Gounder, M, Lin, H, Dvorzhinski, D, Dolfi, S C, Chan, L L-Y, Qiu, J, DiPaola, R S, Hirshfield, K M, Boros, L G, Bertino, J R, Oltvai, Z N, Vazquez, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920946/
https://ncbi.nlm.nih.gov/pubmed/24157871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.393
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