Targeting Müller Cell–Derived VEGF(164) to Reduce Intravitreal Neovascularization in the Rat Model of Retinopathy of Prematurity

PURPOSE. To determine whether knockdown of Müller cell–derived VEGFA-splice variant, VEGF(164,) which is upregulated in the rat retinopathy of prematurity (ROP) model, safely inhibits intravitreal neovascularization (IVNV). METHODS. Short hairpin RNAs for VEGF(164) (VEGF164.shRNAs) or luciferase.shR...

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Detalhes bibliográficos
Main Authors: Jiang, Yanchao, Wang, Haibo, Culp, David, Yang, Zhihong, Fotheringham, Lori, Flannery, John, Hammond, Scott, Kafri, Tal, Hartnett, M. Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920823/
https://ncbi.nlm.nih.gov/pubmed/24425851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13755
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