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Aberrant islet unfolded protein response in type 2 diabetes
The endoplasmic reticulum adapts to fluctuations in demand and copes with stress through an adaptive signaling cascade called the unfolded protein response (UPR). Accumulating evidence indicates that the canonical UPR is critical to the survival and function of insulin-producing pancreatic β-cells,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3920274/ https://ncbi.nlm.nih.gov/pubmed/24514745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04054 |
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