Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance

The very long-chain acyl-CoA dehydrogenase (VLCAD) enzyme catalyzes the first step of mitochondrial β-oxidation. Patients with VLCAD deficiency present with hypoketotic hypoglycemia and cardiomyopathy, which can be exacerbated by fasting and/or cold stress. Global VLCAD knockout mice recapitulate th...

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Detalhes bibliográficos
Main Authors: Xiong, Dingding, He, Huamei, James, Jeanne, Tokunaga, Chonan, Powers, Corey, Huang, Yan, Osinska, Hanna, Towbin, Jeffrey A., Purevjav, Enkhsaikhan, Balschi, James A., Javadov, Sabzali, McGowan, Francis X., Strauss, Arnold W., Khuchua, Zaza
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920141/
https://ncbi.nlm.nih.gov/pubmed/24285112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00931.2012
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