Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4

Pulmonary arterial hypertension is a severe progressive disease with marked morbidity and high mortality in which right ventricular (RV) failure is the major cause of death. Thus knowledge of the mechanisms underlying RV failure is an area of active interest. Previous studies suggest a role of NADPH...

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Autors principals: Frazziano, Giovanna, Al Ghouleh, Imad, Baust, Jeff, Shiva, Sruti, Champion, Hunter C., Pagano, Patrick J.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
Matèries:
Call for Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920131/
https://ncbi.nlm.nih.gov/pubmed/24213612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00977.2012
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