Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep

Intrauterine growth-restricted (IUGR) fetuses experience prolonged hypoxemia, hypoglycemia, and elevated norepinephrine (NE) concentrations, resulting in hypoinsulinemia and β-cell dysfunction. Previously, we showed that acute adrenergic blockade revealed enhanced insulin secretion responsiveness in...

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Bibliographic Details
Main Authors: Chen, Xiaochuan, Green, Alice S., Macko, Antoni R., Yates, Dustin T., Kelly, Amy C., Limesand, Sean W.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920003/
https://ncbi.nlm.nih.gov/pubmed/24253046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00517.2013
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