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Nasal Administration of Recombinant Osteopontin Attenuates Early Brain Injury after Subarachnoid Hemorrhage

BACKGROUND AND PURPOSE: Neuronal apoptosis is a key pathological process in subarachnoid hemorrhage (SAH)-induced early brain injury (EBI). Given that recombinant osteopontin (rOPN), a promising neuroprotectant, cannot pass through the blood-brain barrier (BBB), we aimed to examine whether nasal adm...

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Detalhes bibliográficos
Main Authors: Topkoru, Basak Caner, Altay, Orhan, Duris, Kamil, Krafft, Paul R., Yan, Junhao, Zhang, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919524/
https://ncbi.nlm.nih.gov/pubmed/24008574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.113.001574
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