A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects

The central importance of epigenetics to the aging process is increasingly being recognized. Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA from 718 individuals, aged 25–92 years (mean = 55). We sequenced the methyl-CpG-enriched genomic DNA fraction, averaging...

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Detalhes bibliográficos
Main Authors: McClay, Joseph L., Aberg, Karolina A., Clark, Shaunna L., Nerella, Srilaxmi, Kumar, Gaurav, Xie, Lin Y., Hudson, Alexandra D., Harada, Aki, Hultman, Christina M., Magnusson, Patrik K.E., Sullivan, Patrick F., Van Den Oord, Edwin J.C.G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919012/
https://ncbi.nlm.nih.gov/pubmed/24135035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt511
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