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IN ANTIBODY-POSITIVE FIRST-DEGREE RELATIVES OF PATIENTS WITH TYPE 1 DIABETES, HLA-A24 AND HLA-B18, BUT NOT HLA-B*39, ARE PREDICTORS OF IMPENDING DIABETES WITH DISTINCT HLA-DQ INTERACTIONS

AIMS/HYPOTHESIS: Secondary type 1 diabetes prevention trials require selection of participants with impending diabetes. HLA-A and -B alleles have been reported to promote disease progression. We investigated whether typing for HLA-B*18 and -B*39 may complement screening for HLA-DQ8, -DQ2 and -A*24 a...

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Bibliografske podrobnosti
Main Authors:	Mbunwe, E., Van der Auwera, B. J., Weets, I., Van Crombrugge, P., Crenier, L., Coeckelberghs, M., Seret, N., Decochez, K., Vandemeulebroucke, E., Gillard, P., Keymeulen, B., van Schravendijk, C., Wenzlau, J. M., Hutton, J. C., Pipeleers, D. G., Gorus, F. K., Registry, The Belgian Diabetes
Format:	Artigo
Jezik:	Inglês
Izdano:	2013
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3918938/ https://ncbi.nlm.nih.gov/pubmed/23712485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-2951-8
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IN ANTIBODY-POSITIVE FIRST-DEGREE RELATIVES OF PATIENTS WITH TYPE 1 DIABETES, HLA-A*24 AND HLA-B*18, BUT NOT HLA-B*39, ARE PREDICTORS OF IMPENDING DIABETES WITH DISTINCT HLA-DQ INTERACTIONS

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IN ANTIBODY-POSITIVE FIRST-DEGREE RELATIVES OF PATIENTS WITH TYPE 1 DIABETES, HLA-A24 AND HLA-B18, BUT NOT HLA-B*39, ARE PREDICTORS OF IMPENDING DIABETES WITH DISTINCT HLA-DQ INTERACTIONS