IN ANTIBODY-POSITIVE FIRST-DEGREE RELATIVES OF PATIENTS WITH TYPE 1 DIABETES, HLA-A*24 AND HLA-B*18, BUT NOT HLA-B*39, ARE PREDICTORS OF IMPENDING DIABETES WITH DISTINCT HLA-DQ INTERACTIONS

AIMS/HYPOTHESIS: Secondary type 1 diabetes prevention trials require selection of participants with impending diabetes. HLA-A and -B alleles have been reported to promote disease progression. We investigated whether typing for HLA-B*18 and -B*39 may complement screening for HLA-DQ8, -DQ2 and -A*24 a...

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Main Authors: Mbunwe, E., Van der Auwera, B. J., Weets, I., Van Crombrugge, P., Crenier, L., Coeckelberghs, M., Seret, N., Decochez, K., Vandemeulebroucke, E., Gillard, P., Keymeulen, B., van Schravendijk, C., Wenzlau, J. M., Hutton, J. C., Pipeleers, D. G., Gorus, F. K., Registry, The Belgian Diabetes
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918938/
https://ncbi.nlm.nih.gov/pubmed/23712485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-2951-8
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