IN ANTIBODY-POSITIVE FIRST-DEGREE RELATIVES OF PATIENTS WITH TYPE 1 DIABETES, HLA-A24 AND HLA-B18, BUT NOT HLA-B*39, ARE PREDICTORS OF IMPENDING DIABETES WITH DISTINCT HLA-DQ INTERACTIONS

AIMS/HYPOTHESIS: Secondary type 1 diabetes prevention trials require selection of participants with impending diabetes. HLA-A and -B alleles have been reported to promote disease progression. We investigated whether typing for HLA-B*18 and -B*39 may complement screening for HLA-DQ8, -DQ2 and -A*24 a...

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Bibliografiske detaljer
Main Authors:	Mbunwe, E., Van der Auwera, B. J., Weets, I., Van Crombrugge, P., Crenier, L., Coeckelberghs, M., Seret, N., Decochez, K., Vandemeulebroucke, E., Gillard, P., Keymeulen, B., van Schravendijk, C., Wenzlau, J. M., Hutton, J. C., Pipeleers, D. G., Gorus, F. K., Registry, The Belgian Diabetes
Format:	Artigo
Sprog:	Inglês
Udgivet:	2013
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3918938/ https://ncbi.nlm.nih.gov/pubmed/23712485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-2951-8
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IN ANTIBODY-POSITIVE FIRST-DEGREE RELATIVES OF PATIENTS WITH TYPE 1 DIABETES, HLA-A*24 AND HLA-B*18, BUT NOT HLA-B*39, ARE PREDICTORS OF IMPENDING DIABETES WITH DISTINCT HLA-DQ INTERACTIONS

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IN ANTIBODY-POSITIVE FIRST-DEGREE RELATIVES OF PATIENTS WITH TYPE 1 DIABETES, HLA-A24 AND HLA-B18, BUT NOT HLA-B*39, ARE PREDICTORS OF IMPENDING DIABETES WITH DISTINCT HLA-DQ INTERACTIONS