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Differential Induction of Cytoplasmic Vacuolization and Methuosis by Novel 2-Indolyl-Substituted Pyridinylpropenones

[Image: see text] Because many cancers harbor mutations that confer resistance to apoptosis, there is a need for therapeutic agents that can trigger alternative forms of cell death. Methuosis is a novel form of nonapoptotic cell death characterized by accumulation of vacuoles derived from macropinos...

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Detalhes bibliográficos
Main Authors: Trabbic, Christopher J., Dietsch, Heather M., Alexander, Evan M., Nagy, Peter I., Robinson, Michael W., Overmeyer, Jean H., Maltese, William A., Erhardt, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918887/
https://ncbi.nlm.nih.gov/pubmed/24527179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4003925
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