Chronic hypoxia induces the activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1ΔE9 transgenic mice in vivo

Hypoxia modulates proliferation and differentiation of cultured embryonic and adult stem cells, an effect that includes β-catenin, a key component of the canonical Wnt signaling pathway. Here we studied the effect of mild hypoxia on the activity of the Wnt/β-catenin signaling pathway in the hippocam...

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Autors principals: Varela-Nallar, Lorena, Rojas-Abalos, Macarena, Abbott, Ana C., Moya, Esteban A., Iturriaga, Rodrigo, Inestrosa, Nibaldo C.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918655/
https://ncbi.nlm.nih.gov/pubmed/24574965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00017
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