Epigenetics Meets Genetics in Acute Myeloid Leukemia: Clinical Impact of a Novel Seven-Gene Score

PURPOSE: Molecular risk stratification of acute myeloid leukemia (AML) is largely based on genetic markers. However, epigenetic changes, including DNA methylation, deregulate gene expression and may also have prognostic impact. We evaluated the clinical relevance of integrating DNA methylation and g...

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Hauptverfasser: Marcucci, Guido, Yan, Pearlly, Maharry, Kati, Frankhouser, David, Nicolet, Deedra, Metzeler, Klaus H., Kohlschmidt, Jessica, Mrózek, Krzysztof, Wu, Yue-Zhong, Bucci, Donna, Curfman, John P., Whitman, Susan P., Eisfeld, Ann-Kathrin, Mendler, Jason H., Schwind, Sebastian, Becker, Heiko, Bär, Constance, Carroll, Andrew J., Baer, Maria R., Wetzler, Meir, Carter, Thomas H., Powell, Bayard L., Kolitz, Jonathan E., Byrd, John C., Plass, Christoph, Garzon, Ramiro, Caligiuri, Michael A., Stone, Richard M., Volinia, Stefano, Bundschuh, Ralf, Bloomfield, Clara D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918538/
https://ncbi.nlm.nih.gov/pubmed/24378410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.50.6337
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