Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO, and CCFR Consortia

OBJECTIVE: Genome-wide association studies (GWAS) have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mech...

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Hauptverfasser: Cheng, Iona, Kocarnik, Jonathan M, Dumitrescu, Logan, Lindor, Noralane M, Chang-Claude, Jenny, Avery, Christy L., Caberto, Christian P, Love, Shelly-Ann, Slattery, Martha L, Chan, Andrew T, Baron, John A, Hindorff, Lucia A, Park, Sungshim Lani, Schumacher, Fredrick R, Hoffmeister, Michael, Kraft, Peter, Butler, Anne, Duggan, David, Hou, Lifang, Carlson, Chris S, Monroe, Kristine R, Lin, Yi, Carty, Cara L, Mann, Sue, Ma, Jing, Giovannucci, Edward L, Fuchs, Charles S, Newcomb, Polly A, Jenkins, Mark A, Hopper, John L, Haile, Robert W, Conti, David V, Campbell, Peter T, Potter, John D, Caan, Bette J, Schoen, Robert E, Hayes, Richard B, Chanock, Stephen J, Berndt, Sonja I, Kury, Sebastien, Bezieau, Stephane, Ambite, Jose Luis, Kumaraguruparan, Gowri, Richardson, Danielle, Goodloe, Robert J, Dilks, Holli H, Baker, Paxton, Zanke, Brent W, Lemire, Mathieu, Gallinger, Steven, Hsu, Li, Jiao, Shuo, Harrison, Tabitha, Seminara, Daniela, Haiman, Christopher A, Kooperberg, Charles, Wilkens, Lynne R, Hutter, Carolyn M, White, Emily, Crawford, Dana C, Heiss, Gerardo, Hudson, Thomas J, Brenner, Hermann, Bush, William S, Casey, Graham, Marchand, Loic Le, Peters, Ulrike
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918490/
https://ncbi.nlm.nih.gov/pubmed/23935004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2013-305189
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