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Epistasis and Quantitative Traits: Using Model Organisms to Study Gene-Gene Interactions

The role of epistasis in the genetic architecture of quantitative traits is controversial, despite the biological plausibility that non-linear molecular interactions underpin the genotype-phenotype map. This controversy arises because most genetic variation for quantitative traits is additive. Howev...

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Bibliographic Details
Main Author: Mackay, Trudy F. C.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918431/
https://ncbi.nlm.nih.gov/pubmed/24296533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3627
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