Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.
The S107 IgA kappa-chain myeloma cell line makes an antiphosphocholine antibody of the T15 idiotype. A somatic mutant of this line, U4, makes an immunoglobulin with a single amino acid substitution of an alanine for a glutamic acid at residue 35. This single amino acid change results in a loss of ph...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1984
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391807/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6435121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.18.5841 |
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