NF-κB is a Critical Mediator of BRCA1 induced Chemoresistance

BRCA1 mediates resistance to apoptosis in response to DNA damaging agents, causing BRCA1 wild-type tumours to be significantly more resistant to DNA damage than their mutant counterparts. In this study we demonstrate that following treatment with the DNA damaging agents etoposide or camptothecin, BR...

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Detalhes bibliográficos
Main Authors: Harte, Mary T, Gorski, Julia J, Savage, Kienan I, Purcell, James W, Barros, Eliana M, Burn, Philip M, McFarlane, Cheryl, Mullan, Paul B, Kennedy, Richard D, Perkins, Neil D, Harkin, D Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3917825/
https://ncbi.nlm.nih.gov/pubmed/23435429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.10
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