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Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila
Deregulation of the Hedgehog (Hh) signaling pathway is associated with the development of human cancer including medullobastoma and basal cell carcinoma. Loss of Patched or activation of Smoothened in mouse models increases the occurrence of tumors. Likewise, in a Drosophila eye model, deregulated H...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3917606/ https://ncbi.nlm.nih.gov/pubmed/22677792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mod.2012.05.009 |
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