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Proteolysis inside the membrane is a rate-governed reaction not driven by substrate affinity
Enzymatic cleavage of transmembrane anchors to release proteins from the membrane controls diverse signaling pathways and is implicated in over a dozen diseases. How catalysis works within the viscous, water-excluding, two-dimensional membrane is unknown. We developed an inducible reconstitution sys...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3917317/ https://ncbi.nlm.nih.gov/pubmed/24315097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.10.053 |
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