TARGETING THE MUC1-C ONCOPROTEIN DOWNREGULATES HER2 ACTIVATION AND ABROGATES TRASTUZUMAB RESISTANCE IN BREAST CANCER CELLS

Patients with HER2 positive breast cancer often exhibit intrinsic or acquired resistance to trastuzumab treatment. The transmembrane MUC1-C oncoprotein is aberrantly overexpressed in breast cancer cells and associates with HER2. The present studies demonstrate that silencing MUC1-C in HER2-overexpre...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Raina, Deepak, Uchida, Yasumitsu, Kharbanda, Akriti, Rajabi, Hasan, Panchamoorthy, Govind, Jin, Caining, Kharbanda, Surender, Scaltriti, Maurizio, Baselga, Jose, Kufe, Donald
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916940/
https://ncbi.nlm.nih.gov/pubmed/23912457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.308
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk