TARGETING THE MUC1-C ONCOPROTEIN DOWNREGULATES HER2 ACTIVATION AND ABROGATES TRASTUZUMAB RESISTANCE IN BREAST CANCER CELLS

Patients with HER2 positive breast cancer often exhibit intrinsic or acquired resistance to trastuzumab treatment. The transmembrane MUC1-C oncoprotein is aberrantly overexpressed in breast cancer cells and associates with HER2. The present studies demonstrate that silencing MUC1-C in HER2-overexpre...

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Главные авторы: Raina, Deepak, Uchida, Yasumitsu, Kharbanda, Akriti, Rajabi, Hasan, Panchamoorthy, Govind, Jin, Caining, Kharbanda, Surender, Scaltriti, Maurizio, Baselga, Jose, Kufe, Donald
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916940/
https://ncbi.nlm.nih.gov/pubmed/23912457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.308
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