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Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment

Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is m...

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Détails bibliographiques
Auteurs principaux: Sharghi-Namini, Soheila, Tan, Evan, Ong, Lee-Ling Sharon, Ge, Ruowen, Asada, H. Harry
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916896/
https://ncbi.nlm.nih.gov/pubmed/24504253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04031
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