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Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment

Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is m...

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Detalhes bibliográficos
Main Authors: Sharghi-Namini, Soheila, Tan, Evan, Ong, Lee-Ling Sharon, Ge, Ruowen, Asada, H. Harry
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916896/
https://ncbi.nlm.nih.gov/pubmed/24504253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04031
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