G1 arrest and down-regulation of cyclin E/cyclin-dependent kinase 2 by the protein kinase inhibitor staurosporine are dependent on the retinoblastoma protein in the bladder carcinoma cell line 5637.

The protein kinase inhibitor staurosporine has been shown to induce G1 phase arrest in normal cells but not in most transformed cells. Staurosporine did not induce G1 phase arrest in the bladder carcinoma cell line 5637 that lacks a functional retinoblastoma protein (pRB-). However, when infected wi...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Schnier, J B, Nishi, K, Goodrich, D W, Bradbury, E M
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC39167/
https://ncbi.nlm.nih.gov/pubmed/8650198
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires